Dr. Sathish Srinivasan
The lymphatic vasculature collects interstitial fluid, immune cells and digested lipids and returns them to blood circulation. The health consequences of lymphatic vascular dysfunction include lymphedema, inflammation, atherosclerosis, heart attack, obesity, fibrosis, and high blood pressure. There are currently no treatments for lymphatic disorders. The major goals of my lab are to: A) Define the mechanisms of lymphatic vascular development B) Develop therapeutic approaches to treat lymphatic disorders.
I have published 35 articles in my research career (total citations=2376; h-index=20). My first/last author publications have been cited more than 1000 times in Google scholar. For these publications I have made original discoveries (venous origin of lymphatic vasculature, Coup-TFII as the regulator of PROX1, Wnt/b-catenin signaling as the regulator of valve development, identity and development of lymphovenous valves). I have collaborated with several distinguished investigators in my career with whom I have published papers and obtained grants. I have received recognition from the scientific community in the form of competitive grants, awards, and invitations for lectureship in meetings and research institutions. I regularly review articles related to lymphatic vascular development in journals such as JCI, Nature Communications, Development, Developmental Biology, Vascular Cell, Circulation, Circulation Research, Angiogenesis and Nucleic Acids Research.